KMID : 1033620230500030200
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Clinical and Experimental Reproductive Medicine 2023 Volume.50 No. 3 p.200 ~ p.205
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Ovarian volume is more closely related to the different manifestations of polycystic ovary syndrome than follicle number per ovary
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Qian Gong
Jasmine Ara Haque Shahed Morshed Hurjahan Banu Ahmed Hossain Muhammad Abul Hasanat
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Abstract
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Objective : Polycystic ovary (PCO), a diagnostic component of polycystic ovary syndrome (PCOS), requires either an ovarian volume (OV) criterion or a follicle number per ovary (FNPO) criterion. This study investigated the association of OV and FNPO criteria with various manifestations of PCOS.
Methods : This cross-sectional study was conducted at a university hospital among 100 patients newly diagnosed with PCOS (according to the revised Rotterdam criteria). Fasting blood samples were collected to measure glucose, total testosterone (TT), luteinizing hormone (LH), follicle-stimulating hormone (FSH), lipid, insulin, and hemoglobin A1c levels. An oral glucose tolerance test was performed. Transabdominal or transvaginal ultrasound of the ovaries was done, depending on patients¡¯ marital status. All investigations were conducted in the follicular phase of the menstrual cycle. OV >10 mL and/or FNPO ¡Ã12 indicated PCO. A homeostasis model assessment of insulin resistance (IR) value ¡Ã2.6 indicated IR, and metabolic syndrome (MS) was defined according to the international harmonization criteria.
Results : Seventy-six participants fulfilled the OV criterion, 70 fulfilled the FNPO criterion, and 89 overall had PCO. Both maximum OV and mean OV had a significant correlation with TT levels (r=0.239, p=0.017 and r=0.280, p=0.005, respectively) and the LH/FSH ratio (r=0.212, p=0.034 and r=0.200, p=0.047, respectively). Mean OV also had a significant correlation with fasting insulin levels (r=0.210, p=0.036). Multivariate binary logistic regression analysis showed that IR (odds ratio [OR], 9.429; 95% confidence interval [CI], 1.701 to 52.271; p=0.010) and MS (OR, 7.952; 95% CI, 1.821 to 34.731; p=0.006) had significant predictive associations with OV alone, even after adjustment for age and body mass index.
Conclusion : OV may be more closely related to the androgenic and metabolic characteristics of PCOS than FNPO.
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KEYWORD
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Polycystic ovary syndrome, Androgens, Menstrual cycle, Insulin resistance, Metabolic syndrome
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